Endocrine Abstracts

Prostate cancer (PC), the most commonly diagnosed malignancy among men, is a complex and heterogeneous disease that is highly influenced by the endocrine environment, which makes difficult the identification of novel therapeutic biomarkers to treat this pathology. Somatostatin (SST) is a pleiotropic neuropeptide that exerts its multiple biological functions, including tumor cell regulation, through a family of receptors (named sst1-5). Particularly, in this study we have found...

Background: Sex hormone-binding globulin (SHBG) is a dimeric glycoprotein synthesized in, and secreted from, hepatocytes. SHBG is also expressed in, but not secreted from, the prostate, where its role is unclear. The expression of SHBG is linked to lipid metabolism, and it also modulates transport and availability of androgen. Given its expression in the prostate and role in the androgen signalling axis, we postulated that expression of SHBG will increase in prostate cancer (P...

Glucuronidation is an enzymatic process that terminally inactivates steroid hormones, including estrogens and androgens, thereby influencing carcinogenesis in hormone-dependent cancers. While estrogens drive breast carcinogenesis via the estrogen receptor alpha (ERα), androgens play a critical role as prohormones for estrogen biosynthesis and ligands for the androgen receptor (AR). Herein, the expression and regulation of two androgen inactivating UDP-glucuronosyltransfer...